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http://www.ru.iimas.unam.mx/handle/IIMAS_UNAM/ART23
Autor: | Denis, Antonia |
Otros autores : | Martinez-Nuñez, Mario Alberto Perez-Rueda, Ernesto Tenorio-Salgado, Silvia |
Título : | Dissecting the Repertoire of DNA-Binding Transcription Factors of the Archaeon Pyrococcus furiosus DSM 3638 |
En: | Life (2075-1729), Vol. 8(4), 40, (2018) |
Número completo : | https://www.mdpi.com/2075-1729/8/4 |
Editorial : | MDPI |
Abstract : | In recent years, there has been a large increase in the amount of experimental evidence for diverse archaeal organisms, and these findings allow for a comprehensive analysis of archaeal genetic organization. However, studies about regulatory mechanisms in this cellular domain are still limited. In this context, we identified a repertoire of 86 DNA-binding transcription factors (TFs) in the archaeon Pyrococcus furiosus DSM 3638, that are clustered into 32 evolutionary families. In structural terms, 45% of these proteins are composed of one structural domain, 41% have two domains, and 14% have three structural domains. The most abundant DNA-binding domain corresponds to the winged helix-turn-helix domain; with few alternative DNA-binding domains. We also identified seven regulons, which represent 13.5% (279 genes) of the total genes in this archaeon. These analyses increase our knowledge about gene regulation in P. furiosus DSM 3638 and provide additional clues for comprehensive modeling of transcriptional regulatory networks in the Archaea cellular domain. |
Area del conocimiento : | Biología y Química |
Palabras clave en inglés : | transcription factors DNA-binding domain regulatory interaction archaeon regulatory network |
Fecha de publicación : | 21-may-2018 |
DOI : | http://dx.doi.org/10.3390/life8040040 |
URI : | http://www.ru.iimas.unam.mx/handle/IIMAS_UNAM/ART23 |
Idioma: | Inglés |
Lugar: | Estados Unidos |
Citación : | Denis, A., Martínez-Núñez, M. A., Tenorio-Salgado, S., & Perez-Rueda, E. (2018). Dissecting the repertoire of DNA-binding transcription factors of the archaeon pyrococcus furiosus DSM 3638. Life, 8(4) doi:10.3390/life8040040 |
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